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DMT stands for N, N-Dimethyltryptamine. It is a powerful psychedelic drug, with serotonergic effects on the human brain, which can induce a rapid and intense psychedelic experience, often referred to as a ‘DMT trip’. The DMT experience is usually characterized by visual hallucinations, frequently involving powerful entities, and is often associated with deeper meaning. This meaningful experience is sometimes called a ‘DMT breakthrough’. When used as a recreational drug, DMT can be smoked, snorted, or injected in its crystal form.

The DMT molecule is structurally similar to other psychedelic tryptamines such as 4-AcO-DMT, 5-MeO-DMT, and psilocybin, allowing it to bind to serotonin receptors and induce psychedelic effects.

DMT is found naturally in a variety of plants and has a long history as the psychoactive component in ayahuasca, a thick hallucinogenic tea, which is considered an important element of shamanic tradition in the Upper and Lower Amazon.

Currently, there is limited evidence supporting endogenous DMT production in humans, specifically whether DMT is produced in the brain.

This information page will focus specifically on DMT rather than ayahuasca, for more information on ayahuasca, please